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Why Metrion’s CSO spent 35 years unlocking the potential of ion channels for drug discovery

2019-11-07T12:21:24+00:00

Thank you to the ELRIG Committee and to BioStrata for allowing us to share the below content on our website. The British Pharmacological Society (BPS) ran a special symposium at the ELRIG Drug Discovery 2019 conference yesterday, focused on the importance of targeting ion channels for drug discovery.  As a unique platform to foster the [...]

Why Metrion’s CSO spent 35 years unlocking the potential of ion channels for drug discovery2019-11-07T12:21:24+00:00

Nav1.5(Late) Cardiac Safety Assay on QPatch

2019-09-02T13:16:05+00:00

The Metrion Biosciences team have recently produced a second application note in collaboration with Sophion Bioscience, describing the use of a ∆KPQ LQT3 mutant to create and validate a Nav1.5 (Late) cardiac safety assay on QPatch 48. Herein, we aim to provide a more reliable and accurate Nav1.5(Late) assay, which removes the requirement for costly [...]

Nav1.5(Late) Cardiac Safety Assay on QPatch2019-09-02T13:16:05+00:00

Opportunities for Ion Channel Targeting Antibodies: Current Landscape and Pipeline

2019-08-28T08:54:22+00:00

Metrion Biosciences’ tenth External Speaker Series presentation featured Dr Catherine Hutchings, a highly experienced biologics drug discovery researcher and independent consultant. Dr Hutchings’ presentation included an overview of membrane proteins as drug targets and the evolution of antibody therapeutics technology, spanning isolation of the first mouse monoclonal antibody (mAb) hybridoma to exploitation of the favourable [...]

Opportunities for Ion Channel Targeting Antibodies: Current Landscape and Pipeline2019-08-28T08:54:22+00:00

An Interview with Professor Nikita Gamper

2019-07-02T18:12:59+00:00

Professor Nikita Gamper, the ninth contributor to Metrion Biosciences External Speaker Series, gives a perspective below regarding his ion channel research focus and collaboration activities with scientists from the Hebei Medical University, China.   Q1. You currently split your time between Leeds University and your role as Adjunct Professor of Pharmacology position at Hebei Medical University [...]

An Interview with Professor Nikita Gamper2019-07-02T18:12:59+00:00

ELRIG: Advances in Cell Based Screening – Gothenburg, Sweden

2019-07-02T14:41:13+00:00

ELRIG is a not-for-profit organisation aiming to provide access to high level scientific content, promote innovation in drug discovery and provide networking platforms for the life science community. To implement this, ELRIG hosts conferences throughout the year across various sites, bringing together life science focused researchers from across Europe. ‘Advances in Cell Based Screening’, hosted [...]

ELRIG: Advances in Cell Based Screening – Gothenburg, Sweden2019-07-02T14:41:13+00:00

Ion Channels in Drug Discovery XIX – Satellite event at BPS 2019

2019-08-28T11:47:32+00:00

Ion channels continue to rise in prominence in both academic and commercial areas. Metrion Biosciences, alongside Sophion Bioscience, Nanion Technologies, Evotec and SB Drug Discovery sponsored the “Ion Channels in Drug Discovery XIX” Satellite meeting held on Friday 1st March at the Baltimore Convention Centre, as part of the 63rd annual meeting of the Biophysical [...]

Ion Channels in Drug Discovery XIX – Satellite event at BPS 20192019-08-28T11:47:32+00:00

A summary of the Sixth Cambridge Ion Channel Forum

2019-08-28T09:14:56+00:00

AstraZeneca and Metrion Biosciences again joined forces on April 9 to co-host the 6th Cambridge Ion Channel Forum, held at the Milstein building at Granta Park. The event has been a key feature of the ion channel enthusiasts’ calendar since 2011 and attended by around 65 delegates, who also enjoyed a networking lunch and poster [...]

A summary of the Sixth Cambridge Ion Channel Forum2019-08-28T09:14:56+00:00

Implementation of a kinetic hERG Assay Protocol Using QPatch 48

2019-03-01T15:21:12+00:00

The Metrion Biosciences team recently produced an application note reporting the successful validation of the ‘Milnes’ voltage protocol for hERG screening using a QPatch 48 automated patch clamp (APC) assay platform. First reported in 2010 using the conventional whole cell patch clamp technique (Milnes et al., 2010, J. Pharmacol. Toxicol. Methods, 61(2), 178-191), this assay [...]

Implementation of a kinetic hERG Assay Protocol Using QPatch 482019-03-01T15:21:12+00:00

An Interview with Professor Alistair Mathie

2019-03-01T15:27:50+00:00

Professor Alistair Mathie, one of Metrion's previous external speakers, gives a perspective below regarding his research into two pore domain potassium channels and his involvement in a collaborative project focused on the detection of atrial fibrillation (AF). On the latter topic, Metrion would like to offer its congratulations to Alistair and his colleagues on the Pharmacists [...]

An Interview with Professor Alistair Mathie2019-03-01T15:27:50+00:00

An Interview with Professor Gary Stephens

2018-08-16T13:36:42+00:00

Professor Gary Stephens gives his perspective on his research into calcium channel modulation, cannabinoid-derived anti-epileptic agents; plus biologics and SUMOylation in the field of ion channel modulation. Calcium channels and synaptic transmission are major components of your research career. What inspired you to focus on these areas and what is the basis of your continued [...]

An Interview with Professor Gary Stephens2018-08-16T13:36:42+00:00