Metrion Biosciences and Nanion Technologies look forward to hosting their first collaborative webinar on Tuesday 28th April entitled:
Validation and optimization of automated patch clamp voltage-gated Ca2+ channel assays.
The webinar will feature Metrion’s CSO Dr. Marc Rogers.
Marc will outline the development, optimisation and validation of a range of voltage-gated Ca2+ channel assays on the Patchliner automated patch clamp platform that were subsequently used in an 8 year drug discovery collaboration between Metrion Biosciences and a German pharma company. The project was successful in identifying several lead series of selective, state-dependent inhibitors of Cav2.2 N-type channels for use as novel, non-opioid analgesic. This required the creation of biophysical screening assays to identify the potency of small molecules against the resting and inactivated state of the human neuronal Ca2+ channels Cav2.1 (P/Q type), Cav2.2 and Cav3.2 (T-type), some of which are notoriously difficult in terms of expression levels and current rundown.
Please join us Live or On-Demand! Registration can be found here
Dr. Marc Rogers (CSO, Metrion Biosciences)
Dr. András Horváth (Application Scientist, Nanion Technologies)
Please email firstname.lastname@example.org if you require any additional information or joining instructions.