Metrion Biosciences is a UK-based Contract Research Organization (CRO) focused on delivering a range of high quality ion channel drug discovery services. We provide highly skilled electrophysiology screening services to support client medicinal chemistry optimisation programmes, CiPA compliant cardiac safety profiling assays, neuroscience assays and translational assays. Working closely with our collaborators, we also offer an expert integrated drug discovery service.
Metrion offers flexible business models according to the scope of each programme, with both fee-for-service and collaborative options available.
Metrion has assembled a team of highly expert and dedicated ion channel screening specialists to support diverse ion channel drug discovery projects and modern safety assessment research. We combine in depth target class knowledge and high quality screening assays with experienced and collaborative project managers to keep your research focused upon meeting both objectives and timelines.
Ion Channel Screening
Metrion has developed validated screening assays against an extensive panel of ion channel cell lines using a variety of high quality ion channel screening platforms with a range of throughput capabilities.
Cardiac Safety Screening
Metrion offers screening services against a premium panel of validated Comprehensive in Vitro Proarrhythmia Assay (CiPA) compliant human cardiac ion channel screening assays, which includes hERG.
Metrion offers a number of neuroscience-related ion channel screening assays and platforms. These neuronal ion channel screening assays can be used for native tissue and species selectivity testing, as well as more general neurotoxicology screening of hits and lead candidates.
Metrion are developing a number of phenotypic assays to aid the translation of in vitro cardiac safety and neuroscience data to the preclinical stage. Assays and platforms include conventional electrophysiology, microelectrode array and impedance measurement.
Metrion is located within the Cambridge bio cluster, one of Europe’s largest bioscience research hubs. Our state of the art laboratories at Granta Park house high quality facilities for native and engineered cell line and induced pluripotent stem cell culture, a comprehensive suite of automated patch clamp platforms, multiple manual patch clamp rigs, fluorescence-based screening capability and laboratory data management and reporting systems.