Selected Metrion Staff Publications 2006-2018
Recent advances in targeting ion channels to treat chronic pain. Stevens, E.B.; Stephens, G.J. British Journal of Pharmacology. 2018, 175 (12), 2133-2137
Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. Zidar, N.; Žula, A.; Tomašič, T.; Rogers, M.; Kirby, RW.; Tytgat, J.; Peigneur, S.; Kikelj, D.; Ilaš, J.; Mašič LP. European Journal of Medicinal Chemistry. 2017, 139, 232-241
Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening. Rogers, M.; Zidar, N.; Kikelj, D.; Kirby, R.W. Assay and Drug Development Technologies. 2016, 14 (2),109-130
Novel K+ Channel Targets in Atrial Fibrillation Drug Development – Where Are We? El-Haou, S.; Ford, J.; Milnes, J. Journal of Cardiovascular Pharmacology. 2015, 66 (5), 412-431
Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology Devalla, H.D.; Schwach, V.; Ford, J.W.; Milnes, J.T.; El‐Haou, S.; Jackson, C.; Gkatzis, K.; Elliott, D.A.; de Sousa Lopes, S.M.C.; Mummery, C.L.; Verkerk, A.O.; Passier, R. EMBO Molecular Medicine 2015. 7 (4), 394-410
Synthesis and biological evaluation of piperazine derivatives as novel isoform selective voltage-gated sodium (Nav) 1.3 channel modulators Jukič, M.; Frlan, R.; Chan, F.; Kirby, R.W.; Madge, D.J.; Tytgat, J.; Peigneur, S.; Anderluh, M.; Kikelj, D. Medicinal Chemistry Research. , 24 (6), 2366-2380
Open access to the KCNQ channel: Retigabine and second generation M-current openers. Chapter 10 in: Cox B & Gosling M (Eds.) Ion Channel Drug Discovery. Krupp, J.; Rush, A.M.; Swahn, B.; Main M. Royal Society of Chemistry Publishing. 2015, 238-257
Action of Clathrodin and Analogues on Voltage-Gated Sodium Channels Peigneur, S.; Žula, A.; Zidar, N.; Chan-Porter, F.; Kirby, R.; Madge, D.; Ilaš, J.; Kikelj, D.; Tytgat, J. Marine Drugs. 2014, 12(4), 2132-43
Human Electrophysiological and Pharmacological Properties of XEN-D0101: A Novel Atrial-Selective Kv1.5/IKur Inhibitor. Ford J.; Milnes J.; Wettwer E.; Christ T.; Rogers M.; Sutton K.; Madge D.; Virag L.; Jost N.; Horvath Z.; Matschke K.; Varro A.; Ravens, U. Journal of Cardiovascular Pharmacology. 2013, 61 (5), 408-415
Novel state-dependent voltage-gated sodium channel modulators, based on marine alkaloids from Agelas sponges Hodnik, Ž.; Tomašić, T.; Mašič L.P.; Chan, F.; Kirby, R.W.; Madge D.J.; Kikelj, D. European Journal of Medicinal Chemistry. 2013, 70, 154-64
Ligand- and structure-based virtual screening for clathrodin-derived human voltage-gated sodium channel modulators Tomašić, T.; Hartzoulakis. B.; Zidar. N.; Chan, F.; Kirby R.W.; Madge, D.J.; Peigneur, S.; Tytgat, J.; Kikelj, D. Journal of Chemical Information and Modelling. 2013, 53 (12), 3223-32
Recent advances in electrophysiology-based screening technology and the impact upon ion channel discovery research Southan, A.P.; Clark, G. Methods in Molecular Biology. 2009, 565, 187-208
Voltage-clamp and current-clamp recordings from mammalian DRG neurons. Cummins, T.R.; Rush, A.M.;Estacion, M.; Dib-Hajj, S.D.; Waxman, S.G. Nature Protocols. 2009, 4, 1103-12
Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons. Rush, A.M.; Cummins, T.R.; Waxman, S.G. Journal of Physiology. 2007, 579, 1-14
The role of sodium channels in neuropathic pain. Rogers, M.; Tang L.; Madge, D.; Stevens E. Seminars in cell and developmental biology. 2006, 17 (5), 571-581
A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons. Rush, A.M.; Dib-Hajj, S.D.; Liu, S.; Cummins T.R.; Black, J.A.; Waxman, S.G. Proceedings of the National Academy of Science USA. 2006, 103, 8245-50