Publications

Ion channel drug discovery and modern medicine. Rogers, M.  MedNous, November-December 2019. Article published in the November-December 2019 edition of ‘MedNous’, a publication of Evernow Publishing Ltd.

The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell-derived sensory neurons of erythromelalgia patients. Meents, J.E.; Bressan, E.; Sontag, S.; Foerster, A.; Hautvast, P.; Rösseler, C.; Hampl, M.; Schüler, H.; Goetzke, R.; Le TKC.; Kleggetveit, I.P.; Le Cann, K.; Kerth, C.; Rush, A.M.; Rogers, M.; Kohl, Z.; Schmelz, M.; Wagner, W.; Jørum, E.; Namer, B.; Winner, B.; Zenke, M.; Lampert, A. PAIN, March 22, 2019 – Article in Press

Recent advances in targeting ion channels to treat chronic pain. Stevens, E.B.; Stephens, G.J.  British Journal of Pharmacology. 2018, 175 (12), 2133-2137

Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.  Zidar, N.; Žula, A.; Tomašič, T.; Rogers, M.; Kirby, RW.; Tytgat, J.; Peigneur, S.; Kikelj, D.; Ilaš, J.; Mašič LP.  European Journal of Medicinal Chemistry. 2017, 139, 232-241

Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening. Rogers, M.; Zidar, N.; Kikelj, D.; Kirby, R.W.  Assay and Drug Development Technologies. 2016, 14 (2),109-130 

Novel K⁺ Channel Targets in Atrial Fibrillation Drug Development – Where Are We? El-Haou, S.; Ford, J.; Milnes, J.  Journal of Cardiovascular Pharmacology. 2015, 66 (5), 412-431 

Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology Devalla, H.D.; Schwach, V.; Ford, J.W.; Milnes, J.T.; El‐Haou, S.; Jackson, C.; Gkatzis, K.; Elliott, D.A.; de Sousa Lopes, S.M.C.; Mummery, C.L.; Verkerk, A.O.; Passier, R.  EMBO Molecular Medicine 2015. 7 (4), 394-410

Synthesis and biological evaluation of piperazine derivatives as novel isoform selective voltage-gated sodium (Nav) 1.3 channel modulators Jukič, M.; Frlan, R.; Chan, F.; Kirby, R.W.; Madge, D.J.; Tytgat, J.; Peigneur, S.; Anderluh, M.; Kikelj, D.  Medicinal Chemistry Research. 2015, 24 (6), 2366-2380

Open access to the KCNQ channel: Retigabine and second generation M-current openers. Chapter 10 in: Cox B & Gosling M (Eds.) Ion Channel Drug Discovery. Krupp, J.; Rush, A.M.; Swahn, B.; Main M. Royal Society of Chemistry Publishing. 2015, 238-257

Action of Clathrodin and Analogues on Voltage-Gated Sodium Channels Peigneur, S.; Žula, A.; Zidar, N.; Chan-Porter, F.; Kirby, R.; Madge, D.; Ilaš, J.; Kikelj, D.; Tytgat, J.  Marine Drugs. 2014, 12(4), 2132-43

Human Electrophysiological and Pharmacological Properties of XEN-D0101: A Novel Atrial-Selective Kv1.5/IKur Inhibitor. Ford J.; Milnes J.; Wettwer E.; Christ T.; Rogers M.; Sutton K.; Madge D.; Virag L.; Jost N.; Horvath Z.; Matschke K.; Varro A.; Ravens, U.  Journal of Cardiovascular Pharmacology. 2013, 61 (5), 408-415

Novel state-dependent voltage-gated sodium channel modulators, based on marine alkaloids from Agelas sponges Hodnik, Ž.; Tomašić, T.; Mašič L.P.; Chan, F.; Kirby, R.W.; Madge D.J.; Kikelj, D.  European Journal of Medicinal Chemistry. 2013, 70, 154-64

Ligand- and structure-based virtual screening for clathrodin-derived human voltage-gated sodium channel modulators Tomašić, T.; Hartzoulakis. B.; Zidar. N.; Chan, F.; Kirby R.W.; Madge, D.J.; Peigneur, S.; Tytgat, J.; Kikelj, D.  Journal of Chemical Information and Modelling. 2013, 53 (12), 3223-32

Recent advances in electrophysiology-based screening technology and the impact upon ion channel discovery research Southan, A.P.; Clark, G.  Methods in Molecular Biology. 2009, 565, 187-208

Voltage-clamp and current-clamp recordings from mammalian DRG neurons. Cummins, T.R.; Rush, A.M.;Estacion, M.; Dib-Hajj, S.D.; Waxman, S.G. Nature Protocols. 2009, 4, 1103-12

Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons. Rush, A.M.; Cummins, T.R.;  Waxman, S.G. Journal of Physiology. 2007, 579, 1-14

The role of sodium channels in neuropathic pain. Rogers, M.; Tang L.; Madge, D.; Stevens E.  Seminars in cell and developmental biology. 2006, 17 (5), 571-581

A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons. Rush, A.M.; Dib-Hajj, S.D.; Liu, S.; Cummins T.R.; Black, J.A.; Waxman, S.G. Proceedings of the National Academy of Science USA. 2006, 103, 8245-50