Ion Channel Screening Assay Development
For more than a decade, Metrion’s scientists have been involved in developing, optimising and validating automated and manual patch clamp assays for ion channel targets. We can fully customise ion channel assays at different stages of the screening cascade, from hit finding and medium throughput structure activity studies, through to specialised biophysical and mechanism-of-action studies for hit series or lead compounds. For example, Metrion developed a Kv1.1/(1.2)3 assay on the QPatch that could accurately identify compounds that bind to different channel states. This assay format has been successfully employed for other voltage gated Kv1.x channels, including Kv1.3.