Multi-electrode arrays (MEA) are a powerful tool to investigate the neuronal firing fingerprint of your cells of choice over days, weeks or even months. Neurons are cultured over a large set of electrodes and over time, a network is established with distinct characteristics. Extracellular field potentials are recorded, providing a non-invasive way of monitoring neuronal activity. Cells from different origins can be compared and / or effects of compounds on excitability, connectivity and synchrony investigated.
Applications of this technology include examining potential neurotoxicity of compounds, thereby helping to define safety margins. Alternatively, MEA recordings can be used to verify the desired actions of compounds specifically developed to be active in the central nervous system (CNS) .
At Metrion, we have two different MEA systems. The Axion Maestro is a high throughput device with a total of 768 electrodes that can be utilised in 12, 48 or 96 well formats. Alternatively, we have MED64 from Alpha MED, a lower throughput but highly flexible instrument with 64 electrodes that is better suited to certain applications. See our platform section for more information.