Understanding the effects of test compounds on brain slice tissue
Brain slices are valuable experimental tools which allow electrophysiological recordings from neurons within their functional environs in situ. In contrast to isolated and/or cultured brain cells, brain slices retain the anatomical architecture of the brain tissue and the synaptic circuitry within. This allows a more holistic understanding of the effects of pharmacological compounds on the entire tissue which may directly or indirectly affect neuronal ion channel function and excitatory activity.
By working with us you will have access to many years’ experience of manual patch-clamp recordings from a variety of brain regions.
We use electrophysiological protocols to study passive and active membrane properties, and to elucidate pharmacological and electrophysiological characteristics of neuronal currents and activity-dependent synaptic plasticity and transmission.
We offer:
Electrophysiological studies on acutely prepared rodent brain slices.
Variety of endpoints: Intrinsic firing properties, spontaneous and evoked responses.
Optimised perfusion system for pharmacological studies.