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Metrion Biosciences’ Company brochure
Metrion Biosciences is a world leading provider of ion channel screening services.
We offer high quality, cost-effective and reliable screening services for ion channels to help you achieve your drug discovery needs. Our expertise in the field means we can provide you with the best possible service, tailored to your requirements.
Contact us today for more information on how we can work together to help you achieve your business objectives.
Click below now to download our company brochure or contact us at info@metrionbiosciences.com
Ion Channel Screening
Introduction
Metrion Biosciences ion channel and drug discovery screening expertise enables us to create and provide efficient assays that deliver reliable, high-quality data to accelerate and validate your drug discovery programmes. Metrion specialises in delivering high-quality ion channel screening services using electrophysiology, label-free and fluorescence based platforms.
Our assay technologies include QPatch (Sophion) and Patchliner (Nanion) automated electrophysiology, conventional manual patch clamp, plate-based impedance and multielectrode array techniques, and plate-based imaging using the FlexStation.
Please contact us if you would like any further information on our Ion Channel Screening services.
Cardiac Safety Screening
Introduction
Metrion offers a range of high quality Cardiac Safety Screening assays, including hERG profiling and components of the Comprehensive In Vitro Proarrhythmia Assay (CiPA) initiative. This includes assays that evaluate the proarrhythmic liabilities of compounds using:
- A extensively validated panel of cardiac ion channels, including the six CiPA ion channels, using gigaohm seal quality automated electrophysiology devices.
- Action potentials recorded from human iPSC-derived cardiomyocytes using multi-electrode array and manual patch clamp platforms.
- The viability of human iPSC-derived cardiomyocytes using an impedance platform.
Please contact us if you would like any further information on our Cardiac Safety Screening services.
Neuroscience
Introduction
Metrion offers a range of peripheral and central nervous system (CNS) neuronal assays utilising native rodent tissue and human iPSC-derived neurons. Our neuroscience assays are used for two main drug discovery purposes:
- Neurotoxicity screening
- Confirmation of compound effects in native neuronal systems.
Phenotypic assays using native neurons offer an important translational step to confirm that customer compounds are effective in native tissues that express a wide range of membrane proteins, scaffolding complexes and intracellular signalling cascades. In this way we can confirm that the desired potency and mechanism-of-action are seen in rodent species that are typically used in preclinical animal models. Similarly, the use of human iPSC-derived neurons can help confirm the efficacy of test compounds prior to testing in rare human tissue and give confidence that lead compound candidates may work in human patients as part of clinical trials.
We offer a range of translational CNS and peripheral neuron assays to support our customers’ drug discovery efforts including neuronal ion channels assays and translational neuroscience assays.
These neuronal assays are not limited to testing ion channel modulators, as they are also suitable for assessing the efficacy of ligands directed against GPCRs, kinases, enzymes, intracellular signalling and homeostatic pathways. Our neuroscience assays are well suited to validating drugs designed to treat pain, epilepsy and a variety of CNS diseases, and we can design custom neuronal assay and cell formats for more specific customer needs.
Please contact us if you would like any further information on our Neuroscience services.
Translational Assays
Introduction
Translational Neuronal Assays Metrion has a range of phenotypic assay platforms to enable its customers to validate the efficacy and mechanisms of their compounds in rodent and human neurons to help translate them towards preclinical testing and eventually into clinical trials. These assays use technologies such as manual patch clamp and multi-electode array (MEA) recordings to offer a direct read-out of physiological function in native tissue or human stem cell-derived neurons.
Translational Cardiac Assays High quality cardiac toxicity data generation and interpretation is vital to the efficient progression of a drug discovery campaign. Metrion offers a range of translational cardiac assays and platforms that have been validated using commercially available iPSC-derived cardiomyocyte cell lines.
Using technologies such as manual patch clamp electrophysiology, multi-electrode array (MEA; Maestro platform) or dual MEA/ impedance readouts (CardioExcyte96), Metrion can offer a direct readout of physiological function in the iPSC-derived cardiomyocyte cell line of your choosing.
Please contact us if you would like any further information on our Translational Assay services.
Integrated Drug Discovery
Introduction
Our highly experienced interdisciplinary team provides customers with a fully integrated drug discovery service by bringing together experts in:
- ion channel biology
- medicinal chemistry
- specialist chemistry
- translational biology
- ADMET
- DMPK
This integrated service spans initial assay development, custom assay validation and high throughput screening in 384-well plate-based assays. Metrion provides high quality electrophysiology-based support for medicinal chemistry optimisation of compounds, including an industry-leading suite of cardiac safety profiling assays. We also offer phenotypic assays on MEA and impedance platforms for target validation and mechanism-of-action studies in native rodent and human iPSC cell-based assays to facilitate the successful translation of lead compounds into preclinical and clinical testing.
Please contact us if you would like any further information on our Integrated Drug Discovery services.
Let’s work together
What are your specific ion channel and assay needs?
If you have any questions or would to like discuss your specific assay requirements, we will put you directly in touch with a member of our scientific team. Contact us today to discover more.