Metrion Biosciences Cardiac Safety Screening Services
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Cardiac Translational Assays

Metrion offers a set of reliable and reproducible translational human cardiovascular assays to demonstrate the cardiac safety of your therapeutic compounds in line with current and future CiPA and FDA guidelines.

Introduction to Metrion’s Cardiac Assays services

High quality cardiac toxicity data generation and interpretation is vital to the efficient progression of a drug discovery campaign. Metrion offers a range of translational, phenotypic cardiac assays and platforms that have been validated using a number of commercially available human iPSC-derived cardiomyocyte cell lines. Using technologies such as manual patch clamp electrophysiology, multi-electrode array (MEA; Maestro platform) or dual MEA/impedance readouts (CardioExcyte96), Metrion can offer a direct readout of physiological function and cardiac risk in the iPSC-derived cardiomyocyte cell line- of your choosing.

Manual Patch Assays

Our Expertise

Metrion has considerable expertise working with human iPSC-derived cardiomyocytes on the manual patch clamp platform. The company has access to, and has characterised, a wide range of commercially available cell lines from a number of vendors. Metrion offers services to screen compounds against action potentials and membrane currents recorded from iPSC-derived cardiomyocytes. Furthermore, we provide a cell line characterisation service for companies and vendors looking to commercialise their cell lines.

Fig1 Cardiac conv ephysv2
Figure 1a. Human iPSC cardiac action potential (Nifedipine)
Fig2 Cardiac conv ephysv2
Figure 1b. Human iPSC cardiac action potential (Dofetilitde)

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MEA and Impedance Platforms

Metrion has developed plate-based iPSC-derived cardiomyocyte assays using MEA and impedance platforms to add further depth to our range of CiPA-compliant assays. Metrion has access to, and has characterised, a wide range of commercially available iPSC-derived cardiomyocyte cell lines from a number of vendors. Phenotypic readouts can be correlated with modelling predictions and electrophysiology readouts as part of an integrated CiPA approach.

Figure2 Cardiac Translational Plate based update2
Microelectrode Array and Impedance data – control versus Nifedipine

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Translational Cardiac Assays Resource Library

White Papers
Application notes
Presentations
Posters
Flyers
Publications
Videos
Translational Cardiac Assays Technologies
  • Conventional manual patch clamp electrophysiology
  • Plate-based impedance and microelectrode array techniques
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Let’s work together

What are your specific ion channel and assay needs?

If you have any questions or would to like to discuss your specific assay requirements, we will put you directly in touch with a member of our scientific team. Contact us today to discover more.