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ConnectIONS is Metrion Biosciences’ collection of blogs, articles, interviews and insights from our team and distinguished guests. They share their thoughts, ideas, strategies, and lessons to deliver high-quality ion channel drug discovery.

John Ridley PhD


Improving Cardiac Safety Testing Protocols

The International Council on Harmonization (ICH) S7B and E14 regulatory guidelines were introduced in 2005 to evaluate the proarrhythmic liability of new drugs. They were implemented in response to the discovery that inhibition of a cardiac potassium channel (encoded by hERG) is associated with prolongation of the QT interval and a potentially deadly arrhythmia, Torsades de Pointes.

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Written by John Ridley PhD

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