Metrion Biosciences Ion Channel Screening Services scaled
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Specialist Ion Channel Screening

Accelerate early-stage screening and lead optimisation

Fully customised ion channel assays

We understand the importance of robust, reliable assays in enabling you to make timely, well-informed decisions. Using innovative solutions tailored to your specific target, we focus on rapid delivery of high-quality data to accelerate your early-stage compound screening and lead optimisation programmes.

Our specialist team of ion channel scientists are experts in their field. With over 250 years’ collective ion channel drug discovery experience, we specialise in developing, optimising and validating high-quality ion channel screening services using a range of electrophysiology and fluorescence-based platforms.

We fully customise ion channel assays at different stages of the screening cascade, from high-throughput screening (HTS) and structure-activity relationship (SAR) studies, through to specialised biophysical and mechanism-of-action studies for lead compounds.

KCNC1 kinetic trace and plate statistics
Screening against V434L KCCN1 using thallium flux assay. Read the drug repurposing high-throughput screening case study about a recent project researching a rare de novo variant in the KCNC1 gene.

Reliable data you can trust

Our expertise in electrophysiology and fluorescence-based platforms is what stands us apart, ensuring you receive robust and reliable data.

We strive to exceed our clients’ expectations and to build long-term partnerships based on trust:

  • High quality, cost-efficient compound screening.
  • Rapid reporting and data interpretation by experienced ion channel experts.
  • Tailored, target-focussed assay development, including complex assays.
  • In-house generation and validation of novel ion channel cell lines.
  • Detailed characterisation of lead compounds in a range of complementary assays.
  • Translational services including confirmation of efficacy.
  • Access to commercially available compound libraries (Assay.Works and Enamine) with freedom to operate.

Technologies we use for ion channel screening

State-of-the-art technology is employed to deliver high quality data supported by the latest liquid handling capabilities.


  • Qube 384
  • QPatch-48 (x2) and QPatch-II
  • Volta
  • Patchliner automated electrophysiology
  • Conventional manual patch clamp electrophysiology
  • Plate-based impedance and microelectrode array techniques

Fluorescence and luminescence:

  • FLIPR® Penta
  • FLEXStation III

Liquid handling:

Metrion’s Ion Channel Screening Resource library

Metrion Biosciences Ion Channel Screening Icon Large 01 Ion Channel Screening Resources
Videos and Presentations
Application notes and resources
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Let’s work together

What are your specific ion channel screening requirements?

If you have any questions, or would like to discuss your project, we will put you directly in touch with a member of our scientific team. Contact us today to discover more.