Cure CLCN4 Scientific Conference 2023
Dates and times
June 16th @ 09:00
June 17th @ 17:00
Cure CLCN4 Scientific Conference 2023 – Cure CLCN4
Metrion Biosciences will be attending the conference: Cure CLCN4 Scientific Conference 2023
Metrion will have delegate representation at the event. If you would like to arrange a meeting with the Metrion Team please contact firstname.lastname@example.org.
CLCN4-related neurodevelopmental condition (CLCN4-NDC) is a rare X-linked genetic disorder that leads to intellectual disability and other problems such as epilepsy, behavioural disorders, movement disorders and microcephaly. CLCN4-NDC is caused by mutations in the CLCN4 gene, which encodes the ClC-4 protein, a 2Cl-/H+ ion channel expressed in intracellular compartments in a wide variety of tissues, but prominently in the brain and skeletal muscle. The extent and severity of CLCN4-related condition, which has so far been reported in just over 120 individuals worldwide, is very variable, depending on the type of gene change, the gender of the affected individual, the pathophysiological impact of the genetic change and, as yet, incompletely understood factors. Overall, there is currently little understanding of the basic biology of CIC-4 and no appropriate therapeutic options.
For the second year in a row, this conference will bring together leading academic, clinical and industry speakers from the ion channel, rare disease, and therapeutic discovery fields. Through a series of short talks and panel discussions, we will review the latest knowledge on the biology and clinical aspects of CLCN4-NDC and establish the necessary steps towards the development of therapeutic options for CLCN4, all the way from the early stages of basic research on animal and cellular models to clinical research, drug discovery, and precision medicine.
Venue: Franks Room at the Wellcome Collection in Central London
Location: 183 Euston Road, University of London, London NW12BE
Country: United Kingdom