Nanion User Meeting Virtual Event 2020

//Nanion User Meeting Virtual Event 2020
Loading Events
This event has passed.

Metrion Biosciences are attending the Virtual Nanion User Meeting to be held on 12th to 16th October 2020.

Metrion’s CSO Dr Marc Rogers will be presenting a talk at the event on 14th October entitled:

Development and validation of ASIC1a ligand-gated ion channel drug discovery assays on automated patch clamp platforms.

Abstract:

Whilst voltage-gated ion channels formed the bulk of academic and industrial effort in developing and utilising APC assays for ion channel drug discovery, recent years have seen increasing interest in ligand-gated receptors. These targets offer specific challenges for APC systems in terms of lower channel expression, rapid application and wash-off of ligands, and loss of responsiveness due to short- and long-term desensitisation. In this presentation I will outline successful development of pipette- and tip-based APC assay formats for the rapidly-activating ASIC1A channel on the Patchliner and Syncropatch384i.